For responsive websites, you should present actual, responsive examples for a client’s review. This is where responsive prototypes can be valuable to your process.
Using responsive prototypes is not the same thing as designing in the browser, a practice which many web designers feel stifles their creativity. You can still use your graphics program of choice to establish some visual direction and layout choices, but you should then translate those choices into an interactive presentation.
When designing web pages, there is a temptation to work on the easiest pages first so that you have some deliverables to show your stakeholders. This quicker turnaround may be nice, but in your design process you should focus on the most challenging and extreme scenarios.
Take the common example of designing a page that displays articles (blogs, press releases, case studies, etc). That page is sure to have a title near the top. What happens to the design when that title is two or three times longer than what you have designed for?
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